Rapid improvement of disseminated aspergillosis with caspofungin/voriconazole combination in an adult leukemic patient

被引：26

作者：

Damaj, G

Ivanov, V

Le Brigand, B

D'incan, E

Doglio, MF

Bilger, K

Faucher, C

Vey, N

Gastaut, JA

机构：

[1] Inst J Paoli I Calmettes, Dept Hematol, F-13273 Marseille 9, France

[2] Inst J Paoli I Calmettes, Dept Radiol, F-13273 Marseille 9, France

来源：

ANNALS OF HEMATOLOGY | 2004年 / 83卷 / 06期

关键词：

leukemia; aspergillosis; caspofungin; voriconazole;

D O I：

10.1007/s00277-003-0792-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 57-year-old man with acute myeloid leukemia (AML) French-American-British (FAB) 4 developed disseminated invasive cerebral and pulmonary aspergillosis during postinduction aplasia. According to international consensus, infection was categorized as probable (two host factors: deep neutropenia for >10 days and refractory fever for >96 h; major clinical criteria of lower respiratory tract and CNS invasive fungal infection; positive results for galactomannan antigen in three blood samples). After the failure of standard amphotericin-based therapy, the spectacular regression of multifocal brain and lung lesions was rapidly achieved under a caspofungin acetate/voriconazole combination. Further permanent caspofungin maintenance with voriconazole added during aplasia periods permitted two consolidation courses and autograft-based intensification without any delay.

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收藏

页码：390 / 393

页数：4

相关论文

共 21 条

[1] TREATMENT OF MURINE CANDIDOSIS AND CRYPTOCOCCOSIS WITH A UNILAMELLAR LIPOSOMAL AMPHOTERICIN-B FORMULATION (AMBISOME) [J].

ADLERMOORE, JP ;

CHIANG, SM ;

SATORIUS, A ;

GUERRA, D ;

MCANDREWS, B ;

MCMANUS, EJ ;

PROFFITT, RT .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 28 :63-71

[2] Current and future antifungal therapy: new targets for antifungal therapy [J].

Andriole, VT .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 16 (03) :317-321

[3] Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: An international consensus [J].

Ascioglu, S ;

Rex, JH ;

de Pauw, B ;

Bennett, JE ;

Bille, J ;

Crokaert, F ;

Denning, DW ;

Donnelly, JP ;

Edwards, JE ;

Erjavec, Z ;

Fiere, D ;

Lortholary, O ;

Maertens, J ;

Meis, JF ;

Patterson, TF ;

Ritter, J ;

Selleslag, D ;

Shah, PM ;

Stevens, DA ;

Walsh, TJ .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (01) :7-14

[4] Early investigation and initiation of therapy for invasive pulmonary aspergillosis in leukaemic and bone marrow transplant patients [J].

Barnes, AJ ;

Oppenheim, BA ;

Chang, J ;

Morgenstern, GR ;

Scarffe, JH .

MYCOSES, 1999, 42 (5-6) :403-408

[5] Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery [J].

Caillot, D ;

Casasnovas, O ;

Bernard, A ;

Couaillier, JF ;

Durand, C ;

Cuisenier, B ;

Solary, E ;

Piard, F ;

Petrella, T ;

Bonnin, A ;

Couillault, G ;

Dumas, M ;

Guy, H .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (01) :139-147

[6] Echinocandins: a new class of antifungal [J].

Denning, DW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 49 (06) :889-891

[7] Therapeutic outcome in invasive aspergillosis [J].

Denning, DW .

CLINICAL INFECTIOUS DISEASES, 1996, 23 (03) :608-615

[8] An EORTC multicentre prospective survey of invasive aspergillosis in haematological patients: Diagnosis and therapeutic outcome [J].

Denning, DW ;

Marinus, A ;

Cohen, J ;

Spence, D ;

Herbrecht, R ;

Pagano, L ;

Kibbler, C ;

Kcrmery, V ;

Offner, F ;

Cordonnier, C ;

Jehn, U ;

Ellis, M ;

Collette, L ;

Sylvester, R .

JOURNAL OF INFECTION, 1998, 37 (02) :173-180

[9] Invasive aspergillosis [J].

Denning, DW .

CLINICAL INFECTIOUS DISEASES, 1998, 26 (04) :781-803

[10]

Gatbois E, 2002, J MYCOL MED, V12, P90