Cavity formation before stable hydrogen bonding in the folding of a beta-clam protein

被引：59

作者：

Clark, PL

Liu, ZP

Rizo, J

Gierasch, LM

机构：

[1] UNIV MASSACHUSETTS, DEPT CHEM, AMHERST, MA 01003 USA

[2] UNIV TEXAS, SW MED CTR, MOL BIOPHYS GRAD PROGRAM, DALLAS, TX 75235 USA

[3] UNIV TEXAS, SW MED CTR, DEPT MOL BIOL & ONCOL, DALLAS, TX 75235 USA

[4] UNIV TEXAS, SW MED CTR, DEPT BIOCHEM, DALLAS, TX 75235 USA

[5] UNIV TEXAS, SW MED CTR, DEPT PHARMACOL, DALLAS, TX 75235 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 11期

关键词：

D O I：

10.1038/nsb1197-883

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The time course of folding of a small beta-sheet protein reveals formation of a central ligand binding cavity before the consolidation of the native hydrogen bonding network. These results suggest that side chain interactions and not stable hydrogen bonding determine the beta-sheet architecture and play crucial roles in the overall chain topology.

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页码：883 / 886

页数：4

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