p65/RelA binds and activates the beclin 1 promoter

被引：47

作者：

Copetti, Tamara ^{[1
]}

Demarchi, Francesca ^{[1
]}

Schneider, Claudio ^{[1
,2
]}

机构：

[1] Lab Nazl Consorzio Interuniv Biotecnol, I-34012 Trieste, Italy

[2] Univ Udine, Dipartimento Sci & Tecnol Biomed, I-33100 Udine, Italy

来源：

AUTOPHAGY | 2009年 / 5卷 / 06期

关键词：

p65/RelA; autophagosomes; T lymphocytes; beclin; 1; promoter; transcription; T cell receptor;

D O I：

10.4161/auto.8822

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We unveiled novel p65/RelA consensus sites in the promoter of the beclin 1 gene and demonstrate that p65/RelA positively modulates canonical autophagy in various human cell lines both under basal conditions and upon induction by ceramide. Interestingly, we find that T cell receptor-dependent activation of Jurkat cells triggers an increase in the binding of p65/RelA to the beclin I promoter accompanied by enhanced autophagy, suggesting that p65/RelA could regulate T-cell activation and homeostasis through autophagy.

引用

页码：858 / 859

页数：2