Novel metabolic transformation pathway for cyclic imides in Blastobacter sp strain A17p-4

被引：16

作者：

Ogawa, J ^{[1
]}

Soong, CL ^{[1
]}

Honda, M ^{[1
]}

Shimizu, S ^{[1
]}

机构：

[1] KYOTO UNIV,DEPT AGR CHEM,SAKYO KU,KYOTO 606,JAPAN

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 1996年 / 62卷 / 10期

关键词：

D O I：

10.1128/AEM.62.10.3814-3817.1996

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The metabolic transformation pathway for cyclic imides in microorganisms was studied in Blastobacter sp, strain A17p-4, This novel pathway involves, in turn, hydrolytic ring opening of a cyclic imide to yield a monoamidated dicarboxylate, hydrolytic deamidation of the monoamidated dicarboxylate to yield a dicarboxylate, and dicarboxylate transformation similar to that in the tricarboxylic acid cycle, The initial step is catalyzed by a novel enzyme, imidase. Imidase and subsequent enzymes involved in this metabolic pathway are induced by some cyclic imides, such as succinimide and glutarimide, Induced cells metabolize various cyclic imides.

引用

页码：3814 / 3817

页数：4

共 17 条

[1] REACTIONS OF N-BROMOAMIDES AND N-BROMOIMIDES WITH STYRENE [J].