Effect of neuropeptide Y on inflammatory paw edema in the rat:: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)

被引：34

作者：

Dimitrijevic, M

Stanojevic, S

Vujic, V

Kovacevic-Jovanovic, V

Beck-Sickinger, A

Demuth, HU

von Hörsten, S

机构：

[1] Inst Immunol & Virol Torlak, Immunol Res Ctr Branislav Jankovic, YU-11152 Belgrade, Yugoslavia

[2] Sch Med, Inst Chem, Belgrade, Yugoslavia

[3] Univ Leipzig, Dept Biochem, D-04103 Leipzig, Germany

[4] Probiodrug Res, Bioctr, D-06120 Halle An Der Saale, Germany

[5] Hannover Med Sch, Dept Functional & Appl Anat, D-30625 Hannover, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 129卷 / 1-2期

关键词：

neuropeptide Y (NPY); NPY receptors; dipeptidyl-peptidase IV (DPIV; CD26); paw edema; inflammation; rats;

D O I：

10.1016/S0165-5728(02)00173-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：35 / 42

页数：8

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