Modulation of hepatic stellate cells and reversibility of hepatic fibrosis

被引：220

作者：

Huang, Yu ^{[1
]}

Deng, Xin ^{[2
]}

Liang, Jian ^{[3
]}

机构：

[1] Guangxi Univ Chinese Med, Fac Grad Studies, Nanning 530001, Guangxi Zhuang, Peoples R China

[2] Guangxi Univ Chinese Med, Ruikang Hosp, 10 East China Rd, Nanning 530001, Guangxi Zhuang, Peoples R China

[3] Guangxi Univ Chinese Med, Nanning 530001, Guangxi Zhuang, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2017年 / 352卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Modulation; Hepatic stellate cells; Reversibility; Hepatic fibrosis; Mechanism; RAT-LIVER FIBROSIS; EXTRACELLULAR-MATRIX; TISSUE INHIBITOR; CELLULAR SENESCENCE; NATURAL-KILLER; MESSENGER-RNA; APOPTOSIS; REGRESSION; EXPRESSION; ACTIVATION;

D O I：

10.1016/j.yexcr.2017.02.038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Hepatic fibrosis (HF) is the pathological component of a variety of chronic liver diseases. Hepatic stellate cells (HSC) are the main collagen-producing cells in the liver and their activation promotes HF. If HSC activation and proliferation can be inhibited, HF occurrence and development can theoretically be reduced and even reversed. Over the past ten years, a number of studies have addressed this process, and here we present a review of HSC modulation and HF reversal.

引用

收藏

页码：420 / 426

页数：7

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