Gene-marked autologous hematopoietic stem cell transplantation of autoimmune disease

被引:13
作者
Burt, RK [1 ]
Brenner, M
Burns, W
Courier, E
Firestein, G
Hahn, B
Heslop, H
Link, C
McFarland, H
Roland, M
Territo, M
Tsokos, G
Traynor, A
机构
[1] Northwestern Univ, Med Ctr, Chicago, IL 60611 USA
[2] Rupert H Lurie Canc Ctr, Chicago, IL 60611 USA
[3] Baylor Coll Med, Cell & Gene Therapy Ctr, Houston, TX 77030 USA
[4] Med Coll Wisconsin, Milwaukee, WI 53226 USA
[5] Univ Calif San Diego, San Diego, CA 92103 USA
[6] Univ Calif Los Angeles, Los Angeles, CA USA
[7] Human Gene Therapy Res Inst, Des Moines, IA USA
[8] NIH, Bethesda, MD 20892 USA
[9] Henry M Jackson Fdn Advancement Mil Sci, Rockville, MD USA
关键词
hematopoietic stem cell transplantation; gene-marked autologous stem cells; autoimmune disease;
D O I
10.1023/A:1006673408343
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In phase I(safety) trials, we have demonstrated the feasibility of autologous hematopoietic stem cell transplantation (HSCT) for patients with autoimmune diseases. Although this review comments on results of our phase I trials, the focus is on phase II (efficacy) trials using gene-marked autologous stem cells.
引用
收藏
页码:1 / 9
页数:9
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