A combinatorial approach to catalytic peptide dendrimers

被引：76

作者：

Clouet, A ^{[1
]}

Darbre, T ^{[1
]}

Reymond, JL ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 35期

关键词：

cobalamines; combinatorial chemistry; dendrimers; enzyme models; peptides;

D O I：

10.1002/anie.200460177

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Exploring the structural diversity of peptide dendrimers as synthetic protein models: A 65536-membered combinatorial peptide-dendrimer library was prepared by split-and-mix techniques on beads (see picture). The library was screened and revealed peptide dendrimers that catalyze fluorogenic ester hydrolysis and peptide dendrimers that bind to vitamin B12.

引用

页码：4612 / 4615

页数：4

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