Aging and Chronic Kidney Disease: The Impact on Physical Function and Cognition

被引：94

作者：

Anand, Shuchi ^{[1
]}

Johansen, Kirsten L. ^{[2
,3
]}

Tamura, Manjula Kurella ^{[1
,4
]}

机构：

[1] Stanford Univ, Sch Med, Div Nephrol, Dept Med, Palo Alto, CA 94304 USA

[2] Dept Vet Affairs Med Ctr, Nephrol Sect, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Med, Div Nephrol, San Francisco, CA USA

[4] Palo Alto Vet Affairs Hlth Care Syst, Geriatr Res & Educ Clin Ctr, Palo Alto, CA USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2014年 / 69卷 / 03期

关键词：

Chronic kidney disease; Frailty; Physical function; Cognitive function; SMALL VESSEL DISEASE; CYSTATIN-C; HIP FRACTURE; OLDER-ADULTS; FREQUENT HEMODIALYSIS; ELDERLY PERSONS; WOMENS HEALTH; MILD ANEMIA; FRAILTY; ASSOCIATION;

D O I：

10.1093/gerona/glt109

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Evidence has recently been building that the presence of chronic kidney disease (CKD) is an independent contributor to decline in physical and cognitive functions in older adults. CKD affects 45% of persons older than 70 years of age and can double the risk for physical impairment, cognitive dysfunction, and frailty. To increase awareness of this relatively new concept of CKD as a risk factor for accelerated aging, we review studies on the association of CKD with physical function, frailty, and cognitive function. We also present a summary of the proposed mechanisms for these associations.

引用

页码：315 / 322

页数：8

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