RNA surveillance by nuclear scanning?

被引：93

作者：

Wilkinson, MF ^{[1
]}

Bin Shyu, A

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[2] Univ Texas, Sch Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1038/ncb0602-e144

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There are many quality-control mechanisms that ensure high fidelity of gene expression. One of these is the nonsense-mediated decay (NMD) pathway, which destroys aberrant mRNAs that contain premature termination codons generated as a result of biosynthetic errors or random and programmed gene mutations. Two complexes that initially bind to RNA in the nucleus have been suggested to be involved in NMD in the cytoplasm. Here we propose an alternative model that involves nuclear scanning, on the basis of recent evidence for nuclear translation.

引用

页码：E144 / E147

页数：4

共 43 条

[1] Eukaryote-specific domains in translation initiation factors: Implications for translation regulation and evolution of the translation system [J].

Aravind, L ;

Koonin, EV .

GENOME RESEARCH, 2000, 10 (08) :1172-1184

[2] A splicing-dependent regulatory mechanism that detects translation signals [J].

Carter, MS ;

Li, SL ;

Wilkinson, MF .

EMBO JOURNAL, 1996, 15 (21) :5965-5975

[3] AU-RICH ELEMENTS - CHARACTERIZATION AND IMPORTANCE IN MESSENGER-RNA DEGRADATION [J].

CHEN, CYA ;

SHYU, AB .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (11) :465-470

[4] INTRONS ARE CIS EFFECTORS OF THE NONSENSE-CODON-MEDIATED REDUCTION IN NUCLEAR MESSENGER-RNA ABUNDANCE [J].

CHENG, J ;

BELGRADER, P ;

ZHOU, XB ;

MAQUAT, LE .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (09) :6317-6325

[5] NONSENSE CONDONS CAN REDUCE THE ABUNDANCE OF NUCLEAR MESSENGER-RNA WITHOUT AFFECTING THE ABUNDANCE OF PREMESSENGER RNA OR THE HALF-LIFE OF CYTOPLASMIC MESSENGER-RNA [J].

CHENG, J ;

MAQUAT, LE .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1892-1902

[6] A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5′ cap-binding protein, eIF4E [J].

Dostie, J ;

Ferraiuolo, M ;

Pause, A ;

Adam, SA ;

Sonenberg, N .

EMBO JOURNAL, 2000, 19 (12) :3142-3156

[7] Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles [J].

Dostie, J ;

Lejbkowicz, F ;

Sonenberg, N .

JOURNAL OF CELL BIOLOGY, 2000, 148 (02) :239-245

[8] MONOCLONAL ANTIBODY-AIDED CHARACTERIZATION OF CELLULAR-P220 IN UNINFECTED AND POLIOVIRUS-INFECTED HELA-CELLS - SUBCELLULAR-DISTRIBUTION AND IDENTIFICATION OF CONFORMERS [J].

ETCHISON, D ;

ETCHISON, JR .

JOURNAL OF VIROLOGY, 1987, 61 (09) :2702-2710

[9] The yeast nuclear cap binding complex can interact with translation factor elF4G and mediate translation initiation [J].

Fortes, P ;

Inada, T ;

Preiss, T ;

Hentze, MW ;

Mattaj, IW ;

Sachs, AB .

MOLECULAR CELL, 2000, 6 (01) :191-196

[10]

Gersappe A, 1999, MOL CELL BIOL, V19, P1640

← 1 2 3 4 5 →