Roles of BRCA1 in centrosome duplication

被引：95

作者：

Deng, CX ^{[1
]}

机构：

[1] NIDDKD, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA

来源：

ONCOGENE | 2002年 / 21卷 / 40期

关键词：

BRCA1; GADD45; p53; centrosome amplification;

D O I：

10.1038/sj.onc.1205713

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Centrosome duplication is under precise control and occurs only once in a normal mammalian cell cycle. Disruption of this process causes centrosome amplification, unequal segregation of chromosomes and, ultimately, tumorigenesis. Recent studies indicate that breast cancer suppressor gene 1 (BRCA1) plays an important role in regulating centrosome duplication. BRCA1 is located in the centrosome and binds to gamma-tubulin. It interacts with a variety of proteins that regulate centrosome duplication, including BRCA2, CDK2 - Cyclin A, CDK2 - Cyclin E, Gadd45, p21, p53 and Rb. Furthermore, targeted disruption of murine BRCA1 results in centrosome amplification, suggesting that BRCA1 serves as a negative regulator for centrosome duplication. This review will examine these data and discuss possible relationships between BRCA1 and its interacting proteins in centrosome duplication.

引用

页码：6222 / 6227

页数：6

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