Effect of age and Helicobacter pylori infection on gastric acid secretion

被引：119

作者：

Haruma, K ^{[1
]}

Kamada, T ^{[1
]}

Kawaguchi, H ^{[1
]}

Okamoto, S ^{[1
]}

Yoshihara, M ^{[1
]}

Sumii, K ^{[1
]}

Inoue, M ^{[1
]}

Kishimoto, S ^{[1
]}

Kajiyama, G ^{[1
]}

Miyoshi, A ^{[1
]}

机构：

[1] Hiroshima Univ, Sch Med, Dept Internal Med 1, Gastrointestinal Unit,Minami Ku, Hiroshima 7348551, Japan

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2000年 / 15卷 / 03期

关键词：

age; atrophic gastritis; gastric acid secretion; Helicobacter pylori;

D O I：

10.1046/j.1440-1746.2000.02131.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Whether gastric acid secretion decreases with age is still controversial. With the discovery of Helicobacter pylori, the association of this bacterium with gastric acid secretion has also been discussed. The aim of this study was to investigate the relationship between gastric acid secretion, age and H. pylori infection. Methods: The presence of H. pylori infection, the grade of fundic atrophic gastritis (FAG), and gastric acid secretion were investigated in 280 subjects without localized lesions in the upper gastrointestinal tract. Helicobacter pylori infection was confirmed by Giemsa and immunohistochemical staining, and FAG of biopsy specimens was graded on a scale of 0-4. Results: Both basal and maximal acid output decreased with age in H. pylori-positive subjects, while they did not change with age in H. pylori-negative subjects. Gastric acid secretion decreased with the progression of FAG. An age-correlated decrease in gastric acid secretion in H. pylori-positive subjects depended on an increasing prevalence of FAG with age. Conclusions: In the population studied, advancing age had no influence on gastric acid secretion in H. pylori-negative subjects. Gastric acid secretion decreases with age in H. pylori-positive subjects because of the increasing prevalence of FAG with age. (C) 2000 Blackwell Science Asia Pty Ltd.

引用

页码：277 / 283

页数：7

共 44 条

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