Effects of the movement of insertion sequences on the structure of VanA glycopeptide resistance elements in Enterococcus faecium

被引：31

作者：

Darini, ALC ^{[1
]}

Palepou, MFI ^{[1
]}

Woodford, N ^{[1
]}

机构：

[1] Cent Publ Hlth Lab, ARMRL, London NW9 5HT, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 05期

关键词：

D O I：

10.1128/AAC.44.5.1362-1364.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A Tn1546-related element with IS1216V at position 8839 underwent a structural change after storage of the host strain of Enterococcus faecium at 4 degrees C. The element acquired IS1542 at position 3932, nucleotides 8732 to 8831 were deleted, and the first 3417 nucleotides were lost and replaced by an inverted copy of the IS1216V-vanY-vanZ-inverted-repeat block from the 3' end. Insertion sequence movement is likely to play a key role in the evolution of VanA. resistance elements.

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页码：1362 / 1364

页数：3

相关论文

共 10 条

[1] CHARACTERIZATION OF TN1546, A TN3-RELATED TRANSPOSON CONFERRING GLYCOPEPTIDE RESISTANCE BY SYNTHESIS OF DEPSIPEPTIDE PEPTIDOGLYCAN PRECURSORS IN ENTEROCOCCUS-FAECIUM BM4147 [J].

ARTHUR, M ;

MOLINAS, C ;

DEPARDIEU, F ;

COURVALIN, P .

JOURNAL OF BACTERIOLOGY, 1993, 175 (01) :117-127

[2]

Darini ALD, 1999, FEMS MICROBIOL LETT, V173, P341

[3] HETEROGENEITY OF THE VANA GENE-CLUSTER IN CLINICAL ISOLATES OF ENTEROCOCCI FROM THE NORTHEASTERN UNITED-STATES [J].

HANDWERGER, S ;

SKOBLE, J ;

DISCOTTO, LF ;

PUCCI, MJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (02) :362-368

[4] Molecular analysis of Tn1546 in Enterococcus faecium isolated from animals and humans [J].

Jensen, LB ;

Ahrens, P ;

Dons, L ;

Jones, RN ;

Hammerum, AM ;

Aarestrup, FM .

JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (02) :437-442

[5] Identification and characterization of IS1476, an insertion sequence-like element that disrupts VanY function in a vancomycin-resistant Enterococcus faecium strain [J].

MacKinnon, MG ;

Drebot, MA ;

Tyrrell, GJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (08) :1805-1807

[6] Molecular analysis of diverse elements mediating VanA glycopeptide resistance in enterococci [J].

Palepou, MFI ;

Adebiyi, AMA ;

Tremlett, CH ;

Jensen, LB ;

Woodford, N .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (05) :605-612

[7] Variation in structure and location of VanA glycopeptide resistance elements among enterococci from a single patient [J].

Tremlett, CH ;

Brown, DFJ ;

Woodford, N .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (03) :818-820

[8] Molecular diversity and evolutionary relationships of Tn1546-like elements in enterococci from humans and animals [J].

Willems, RJL ;

Top, J ;

van den Braak, N ;

van Belkum, A ;

Mevius, DJ ;

Hendriks, G ;

van Santen-Verheuvel, M ;

van Embden, JDA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (03) :483-491

[9] Plasmid-mediated vanB glycopeptide resistance in enterococci [J].

Woodford, N ;

Morrison, D ;

Johnson, AP ;

Bateman, AC ;

Hastings, JGM ;

Elliott, TSJ ;

Cookson, B .

MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 1995, 1 (03) :235-240

[10] Diversity of VanA glycopeptide resistance elements in enterococci from humans and nonhuman sources [J].

Woodford, N ;

Adebiyi, AMA ;

Palepou, MFI ;

Cookson, BD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (03) :502-508