TB vaccine strategies - What is needed to solve a complex problem?

被引：30

作者：

Dietrich, Jes ^{[1
]}

Lundberg, Carina Vingsbo ^{[1
]}

Andersen, Peter ^{[1
]}

机构：

[1] Statens Serum Inst, Dept Immunol & Infect Dis, DK-2300 Copenhagen, Denmark

来源：

TUBERCULOSIS | 2006年 / 86卷 / 3-4期

关键词：

tuberculosis; bacterial; vaccination; BCG; latency;

D O I：

10.1016/j.tube.2006.01.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

An estimated 2 billion people are latently infected with Mycobacterium tuberculosis the majority of which are already BCG vaccinated and repeatedly sensitized to mycobacterial strains from the environment. To be successful in the high endemic regions, any future TB vaccine strategy will have to be tailored in accordance with the resulting complexity of the TB infection and anti - mycobacterial immune response. In this review we will discuss some of the most advanced attempts to address this challenge. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：163 / 168

页数：6

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