Synthesis and biological validation of a ubiquitous quorum-sensing molecule

被引：77

作者：

Meijler, MM

Hom, LG

Kaufmann, GF

McKenzie, KM

Sun, CZ

Moss, JA

Matsushita, M

Janda, KD

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 16期

关键词：

autoinducers; bioluminescence; molecular recognition; sensors; signal transduction;

D O I：

10.1002/anie.200353150

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemical communication ("quorum sensing") amongst bacteria has been studied by the synthesis and study of enantiopure (R)-4,5-dihydroxy-2,3- pentanedione (DPD, see scheme). Bioactivity assays with DPD have shown that chelation of boron by the cyclic form of DPD appears to be essential for full induction of bioluminescence, which is an example of quorum-sensing-controlled behavior.

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页码：2106 / 2108

页数：3

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