Modulatory role of adenosine and its receptors in epilepsy: Possible therapeutic approaches

被引：50

作者：

Pagonopoulou, O. ^{[1
]}

Efthimiadou, A. ^{[1
]}

Asimakopoulos, B. ^{[1
]}

Nikolettos, N. K. ^{[1
]}

机构：

[1] Democritus Univ Thrace, Physiol Lab, Sch Med, Alexandroupolis 68100, Greece

来源：

NEUROSCIENCE RESEARCH | 2006年 / 56卷 / 01期

关键词：

adenosinergic system; epilepsy modulation; therapeutic approach;

D O I：

10.1016/j.neures.2006.05.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Adenosine is considered to be the brain's endogenous anticonvulsant as many studies have showed and it is responsible for seizure arrest and postictal refractoriness. Alterations in the adenosinergic system (adenosine and its receptors) have been referred by many previous studies indicating that deficiencies or modifi cations in the function of this purinergic system may contribute to epileptogenesis. Due to this emerging implication of adenosine in the managing of seizures, a new field of adenosine-based therapies has been introduced including adenosine itself, adenosine receptor agonists and antagonists and adenosine kinase inhibitors. The method with the least side effects (heart rate, blood pressure, temperature or even sedation) is being quested including intracerebral implantation of adenosine releasing cells or devices. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：14 / 20

页数：7

共 84 条

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