Hindered rotation congeners of mazapertine: High affinity ligands for the 5-HT1A receptor

被引：14

作者：

Baxter, EW

Reitz, AB

机构：

[1] R. W. Johnson Pharmaceutical Res. I., Drug Discovery, Spring House, PA 19477, Welsh and McKean Roads

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(97)00074-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hindered rotation analogs of the antipsychotic mazapertine (1) were prepared. These compounds exhibited high affinity for the 5-HT1A receptor, but not for other serotonin or dopamine receptors. The related beta-carboline structures were also synthesized and were found to be potent 5-HT1A ligands. (C) 1997 Elsevier Science Ltd.

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页码：763 / 768

页数：6

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