Utility of Magnetic Resonance Imaging Versus Histology for Quantifying Changes in Liver Fat in Nonalcoholic Fatty Liver Disease Trials

被引:509
作者
Noureddin, Mazen [1 ]
Lam, Jessica [2 ]
Peterson, Michael R. [3 ]
Middleton, Michael [2 ]
Hamilton, Gavin [2 ]
Thuy-Anh Le [1 ]
Bettencourt, Ricki [4 ]
Changchien, Chris [2 ]
Brenner, David A. [1 ]
Sirlin, Claude [2 ]
Loomba, Rohit [1 ,4 ,5 ]
机构
[1] Univ Calif San Diego, Dept Med, Div Gastroenterol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA
[3] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA
[4] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, San Diego, CA 92103 USA
[5] San Diego Integrated NAFLD Res Consortium, San Diego, CA USA
基金
美国国家卫生研究院;
关键词
HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA; MACROVESICULAR HEPATIC STEATOSIS; UNITED-STATES; STEATOHEPATITIS; QUANTIFICATION; SPECTROSCOPY; PREVALENCE; NAFLD; CT; CHOLESTEROL;
D O I
10.1002/hep.26455
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
The magnetic resonance imaging-estimated proton density fat fraction (MRI-PDFF) is a novel imaging-based biomarker that allows fat mapping of the entire liver, whereas the magnetic resonance spectroscopy-measured proton density fat fraction (MRS-PDFF) provides a biochemical measure of liver fat in small regions of interest. Cross-sectional studies have shown that MRI-PDFF correlates with MRS-PDFF. The aim of this study was to show the utility of MRI-PDFF in assessing quantitative changes in liver fat through a three-way comparison of MRI-PDFF and MRS-PDFF with the liver histology-determined steatosis grade at two time points in patients with nonalcoholic fatty liver disease (NAFLD). Fifty patients with biopsy-proven NAFLD who participated in a randomized trial underwent a paired evaluation with liver biopsy, MRI-PDFF, and MRS-PDFF at the baseline and 24 weeks. The mean age and body mass index were 47.8 +/- 11.7 years and 30.7 +/- 6.5 kg/m(2), respectively. MRI-PDFF showed a robust correlation with MRS-PDFF both at week 0 and at week 24 (r=0.98, P<0.0001 for both). Cross-sectionally, MRI-PDFF and MRS-PDFF increased with increases in the histology-determined steatosis grade both at week 0 and at week 24 (P<0.05 for all). Longitudinally, patients who had a decrease (1%) or increase (1%) in MRI-PDFF (confirmed by MRS-PDFF) showed a parallel decrease or increase in their body weight and serum alanine aminotransferase and aspartate aminotransferase levels at week 24 (P<0.05). This small increase or decrease in liver fat could not be quantified with histology. Conclusion: In this longitudinal study, MRI-PDFF correlated well with MRS-PDFF and was more sensitive than the histology-determined steatosis grade in quantifying increases or decreases in the liver fat content. Therefore, it could be used to quantify changes in liver fat in future clinical trials. (Hepatology 2013; 58:1930-1940)
引用
收藏
页码:1930 / 1940
页数:11
相关论文
共 41 条
[1]
Current concepts: Liver biopsy. [J].
Bravo, AA ;
Sheth, SG ;
Chopra, S .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (07) :495-500
[2]
Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity [J].
Browning, JD ;
Szczepaniak, LS ;
Dobbins, R ;
Nuremberg, P ;
Horton, JD ;
Cohen, JC ;
Grundy, SM ;
Hobbs, HH .
HEPATOLOGY, 2004, 40 (06) :1387-1395
[3]
Relaxation effects in the quantification of fat using gradient echo imaging [J].
Bydder, Mark ;
Yokoo, Takeshi ;
Hamilton, Gavin ;
Middleton, Michael S. ;
Chavez, Alyssa D. ;
Schwimmer, Jeffrey B. ;
Lavine, Joel E. ;
Sirlin, Claude B. .
MAGNETIC RESONANCE IMAGING, 2008, 26 (03) :347-359
[4]
Assessment of liver fat quantification in the presence of iron [J].
Bydder, Mark ;
Shiehmorteza, Masoud ;
Yokoo, Takeshi ;
Sugay, Sebastian ;
Middleton, Michael S. ;
Girard, Olivier ;
Schroeder, Michael E. ;
Wolfson, Tanya ;
Gamst, Anthony ;
Sirlin, Claude .
MAGNETIC RESONANCE IMAGING, 2010, 28 (06) :767-776
[5]
The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association [J].
Chalasani, Naga ;
Younossi, Zobair ;
Lavine, Joel E. ;
Diehl, Anna Mae ;
Brunt, Elizabeth M. ;
Cusi, Kenneth ;
Charlton, Michael ;
Sanyal, Arun J. .
HEPATOLOGY, 2012, 55 (06) :2005-2023
[6]
Non-High-Density Lipoprotein Cholesterol as a Biomarker for Nonalcoholic Steatohepatitis [J].
Corey, Kathleen E. ;
Lai, Michelle ;
Gelrud, Louis G. ;
Misdraji, Joseph ;
Barlow, Lydia L. ;
Zheng, Hui ;
Andersson, Karin L. ;
Thiim, Michael ;
Pratt, Daniel S. ;
Chung, Raymond T. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2012, 10 (06) :651-656
[7]
Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications [J].
Cusi, Kenneth .
GASTROENTEROLOGY, 2012, 142 (04) :711-U109
[8]
The prevalence of non-alcoholic fatty liver disease and metabolic syndrome in obese children [J].
Gupta, Rishi ;
Bhangoo, Amrit ;
Matthews, Nicole A. V. ;
Anhalt, Henry ;
Matta, Yesu ;
Lamichhane, Basant ;
Malik, Shahid ;
Narwal, Shivinder ;
Wetzler, Graciela ;
Ten, Svetlana .
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2011, 24 (11-12) :907-911
[9]
In vivo characterization of the liver fat 1H MR spectrum [J].
Hamilton, Gavin ;
Yokoo, Takeshi ;
Bydder, Mark ;
Cruite, Irene ;
Schroeder, Michael E. ;
Sirlin, Claude B. ;
Middleton, Michael S. .
NMR IN BIOMEDICINE, 2011, 24 (07) :784-790
[10]
T1 Independent, T2* Corrected Chemical Shift Based Fat-Water Separation With Multi-peak Fat Spectral Modeling Is an Accurate and Precise Measure of Hepatic Steatosis [J].
Hines, Catherine D. G. ;
Frydrychowicz, Alex ;
Hamilton, Gavin ;
Tudorascu, Dana L. ;
Vigen, Karl K. ;
Yu, Huanzhou ;
McKenzie, Charles A. ;
Sirlin, Claude B. ;
Brittain, Jean H. ;
Reeder, Scott B. .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2011, 33 (04) :873-881