Copper sulfate-pentahydrate-1,10-phenanthroline catalyzed amidations of alkynyl bromides. Synthesis of heteroaromatic amine substituted ynamides

被引:294
作者
Zhang, YS [1 ]
Hsung, RP [1 ]
Tracey, MR [1 ]
Kurtz, KCM [1 ]
Vera, EL [1 ]
机构
[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA
关键词
D O I
10.1021/ol049827e
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A practical cross-coupling of amides with alkynyl bromides using catalytic CuSO(4)(.)5H(2)O and 1,10-phenanthroline is described here. This catalytic protocol is more environmentally friendly than the use of CuCN or copper halides and provides a general entry for syntheses of ynamides including various new sulfonyl and heteroaromatic amine substituted ynamides. Given the interest in ynamides, this N-alkynylation of amides should be significant for the future of ynamides in organic synthesis.
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收藏
页码:1151 / 1154
页数:4
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