Safety and feasibility of intramyocardial versus intracoronary delivery of autologous cell therapy in advanced heart failure: the REGENERATE-IHD pilot study

被引：3

作者：

Mozid, Abdul ^{[1
]}

Yeo, Chia ^{[1
]}

Arnous, Samer ^{[1
]}

Ako, Emmanuel ^{[1
]}

Saunders, Natalie ^{[2
]}

Locca, Didier ^{[1
]}

Brookman, Pat ^{[1
]}

Archbold, R. Andrew ^{[1
]}

Rothman, Martin ^{[1
]}

Mills, Peter ^{[1
]}

Agrawal, Samir ^{[2
]}

Martin, John ^{[3
]}

Mathur, Anthony ^{[4
]}

机构：

[1] Barts Hlth Trust, London Chest Hosp, Dept Cardiol, London E2 9JX, England

[2] Barts Hlth NHS Trust, Stem Cell Lab, London, England

[3] UCL, British Heart Fdn Labs, Dept Med, London WC1E 6JJ, England

[4] Queen Mary Univ London, Ctr Clin Pharmacol, Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent,William Harvey Res, London EC1M 6BQ, England

来源：

REGENERATIVE MEDICINE | 2014年 / 9卷 / 03期

基金：

英国医学研究理事会;

关键词：

autologous bone marrow-derived stem/progenitor cells; chronic ischemic heart failure; granulocyte-colony stimulating factor; intracoronary delivery; intramyocardial delivery; COLONY-STIMULATING FACTOR; MARROW MONONUCLEAR-CELLS; CORONARY-ARTERY-DISEASE; STEM-CELLS; PROGENITOR CELLS; TRANSPLANTATION; INJECTION; MYOCARDIUM; REPAIR;

D O I：

10.2217/RME.14.3

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Aim: This study presents an interim safety and feasibility analysis of the REGENERATE-IHD randomized controlled trial, which is examining the safety and efficacy of three different delivery routes of bone marrow-derived stem cells (BMSCs) in patients with ischemic heart failure. Methods & results: The first 58 patients recruited to the REGENERATE-IHD study are included in this interim analysis (pilot). Symptomatic patients with ischemic heart failure were randomized to receive subcutaneous granulocyte colony-stimulating factor or saline injections only; or subcutaneous granulocyte colony-stimulating factor injections followed by intracoronary or intramyocardial injections of BMSCs or serum (control). No significant differences were found in terms of safety and feasibility between the different delivery routes, with no significant difference in procedural complications or major adverse cardiac events. There was a signal towards improved heart failure symptoms in the patients treated with intramyocardial injection of mobilized BMSCs. Conclusion: Peripheral mobilization of BMSCs with or without subsequent direct myocardial delivery appears safe and feasible in patients with chronic ischemic heart failure.

引用

页码：269 / 278

页数：10

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