Plasma 25,OH Vitamin D Concentrations Are Not Associated with Rheumatoid Arthritis (RA)-related Autoantibodies in Individuals at Elevated Risk for RA

被引：40

作者：

Feser, Marie ^{[1
,2
]}

Derber, Lezlie A. ^{[2
]}

Deane, Kevin D. ^{[2
]}

Lezotte, Dennis C. ^{[3
]}

Weisman, Michael H. ^{[4
]}

Buckner, Jane H. ^{[5
]}

Mikuls, Ted ^{[6
]}

O'Dell, James ^{[6
]}

Gregersen, Peter K. ^{[7
]}

Holers, V. Michael ^{[2
]}

Norris, Jill M. ^{[1
]}

机构：

[1] Univ Colorado, Colorado Sch Publ Hlth, Dept Epidemiol, Denver, CO 80202 USA

[2] Univ Colorado Denver, Dept Med, Div Rheumatol, Aurora, CO USA

[3] Univ Colorado, Colorado Sch Publ Hlth, Dept Biostat, Denver, CO 80202 USA

[4] Cedars Sinai Med Ctr, Div Rheumatol, Los Angeles, CA 90048 USA

[5] Benaroya Res Inst, Translat Res Program, Seattle, WA USA

[6] Univ Nebraska Med Ctr, Dept Internal Med, Sect Rheumatol & Immunol, Omaha, NE USA

[7] Feinstein Inst Med Res, Manhasset, NY USA

来源：

JOURNAL OF RHEUMATOLOGY | 2009年 / 36卷 / 05期

基金：

美国国家卫生研究院;

关键词：

VITAMIN D; RHEUMATOID ARTHRITIS; AUTOANTIBODIES; CYCLIC CITRULLINATED PEPTIDE; D METABOLITES; D DEFICIENCY; WOMEN;

D O I：

10.3899/jrheum.080764

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA. Methods. In 1210 Subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was Measured in these cases and 154 autoantibody-negative controls from this cohort. Results. 25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63). Conclusion. Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA. (First Release March 15 2009; J Rheumatol, 2009;36:943-6; doi: 10.3899/jrheum.080764)

引用

页码：943 / 946

页数：4

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