Palladium-catalyzed regiocontrolled α-arylation of trimethylsilyl enol ethers with aryl halides

被引：53

作者：

Iwama, Tetsuo ^{[1
]}

Rawal, Viresh H. ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 25期

关键词：

D O I：

10.1021/ol062093g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Inter- and intramolecular arylations of trimethylsilyl enol ethers with aryl halides are accomplished regiospecifically in the presence of a palladium catalyst and tributyltin fluoride in refluxing benzene or toluene. The optimal catalyst system called for the use of Pd-2(dba)(3) and tri-tert-butylphosphine in ca. 1:2 ratio. Aryl iodides, bromides, and chlorides are all effective arylation partners in this reaction.

引用

页码：5725 / 5728

页数：4

共 69 条

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