Decreased levels of serum brain-derived neurotrophic factor in drug-naive first-episode schizophrenia: relationship to clinical phenotypes

被引:130
作者
Chen, Da Chun [2 ]
Wang, Jing [3 ]
Wang, Bo [4 ]
Yang, Sheng Chang [3 ]
Zhang, Chong Xi [5 ]
Zheng, You Lan [4 ]
Li, Yan Li [2 ]
Wang, Ning [2 ]
Yang, Ke Bing [2 ]
Xiu, Mei Hong [2 ]
Kosten, Thomas R. [1 ]
Zhang, Xiang Yang [1 ]
机构
[1] Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
[2] Beijing Huilongguan Hosp, Beijing, Peoples R China
[3] Guangxi Normal Univ, Coll Life Sci, Guilin 541004, Peoples R China
[4] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China
[5] Shandong Univ Weihai, Marine Coll, Shandong Weihai 264209, Peoples R China
关键词
Schizophrenia; Brain-derived neurotrophic factor; First-episode psychosis; Psychopathology; Neurotrophin; LONG-TERM TREATMENT; BDNF LEVELS; VAL66MET POLYMORPHISM; RAT; EXPRESSION; TRANSPORT; DOPAMINE;
D O I
10.1007/s00213-009-1665-6
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
There is accumulating evidence that brain-derived neurotrophic factor (BDNF) may be involved in the pathophysiology of patients with schizophrenia. Clinical studies show reductions in BDNF in schizophrenic patients treated with first generation antipsychotics or second generation antipsychotics. However, there have been few systematic studies to examine the relationship between BDNF levels and psychopathology in first-episode and drug-na < ve patients with schizophrenia. Serum BDNF levels were determined using enzyme-linked-immunosorbent assay (ELISA) in the serum of 88 never-medicated first-episode and 90 healthy controls subjects matched for age and gender. The schizophrenia symptomatology and the depressive symptoms were assessed by the positive and negative syndrome scale (PANSS) and the Hamilton rating (HAMD) scale for depression. The results showed that BDNF levels were significantly lower in first-episode patients with schizophrenia than in healthy control subjects (9.0 +/- 4.2 ng/ml vs 12.1 +/- 2.2 ng/ml; F = 37.6; df = 1, 176; p < 0.0001). A significant positive correlation between BDNF levels and PANSS positive subscore was observed (r = 0.29; df = 88; p = 0.008). Furthermore, higher BDNF levels were observed in patients with paranoid subtype of schizophrenia. However, no significant correlation between BDNF and HAMD total score was found. Low BDNF levels at the onset of psychosis suggest that it may contribute to the pathogenesis of schizophrenia and perhaps, could be a candidate biological marker for positive symptoms.
引用
收藏
页码:375 / 380
页数:6
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