Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans

被引：55

作者：

Olsen, Anders ^{[1
]}

Vantipalli, Maithili C. ^{[1
]}

Lithgow, Gordon J. ^{[1
]}

机构：

[1] Buck Inst, Novato, CA 94945 USA

来源：

SCIENCE | 2006年 / 312卷 / 5778期

关键词：

D O I：

10.1126/science.1124981

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.

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页码：1381 / 1385

页数：5

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