Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents

被引：42

作者：

Cooper, N ^{[1
]}

Hagan, DR ^{[1
]}

Tiberghien, A ^{[1
]}

Ademefun, T ^{[1
]}

Matthews, CS ^{[1
]}

Howard, PW ^{[1
]}

Thurston, DE ^{[1
]}

机构：

[1] Univ London, Sch Pharm, CRUK Gene Targeted Drug Design Res Grp, London WC1N 1AX, England

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 16期

关键词：

D O I：

10.1039/b205136b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three novel C2-aryl substituted pyrrolobenzodiazepines (PBDs) have been synthesised and evaluated in a number of cell lines revealing selective cytotoxicity at the sub-nanomolar level towards melanoma and ovarian cancer cell lines.

引用

页码：1764 / 1765

页数：2

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