OWEN: aligning long collinear regions of genomes

被引：47

作者：

Ogurtsov, AY

Roytberg, MA

Shabalina, SA

Kondrashov, AS

机构：

[1] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20892 USA

[2] Inst Math Problems Biol, Pushchino 142290, Moscow Region, Russia

来源：

BIOINFORMATICS | 2002年 / 18卷 / 12期

关键词：

D O I：

10.1093/bioinformatics/18.12.1703

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

OWEN is an interactive tool for aligning two long DNA sequences that represents similarity between them by a chain of collinear local similarities. OWEN employs several methods for constructing and editing local similarities and for resolving conflicts between them. Alignments of sequences of lengths over 10(6) can often be produced in minutes. OWEN requires memory below 20 L, where L is the sum of lengths of the compared sequences.

引用

页码：1703 / 1704

页数：2