Molecular pathology of mixed-lineage leukemia

被引：14

作者：

Bach, Christian ^{[1
]}

Slany, Robert K. ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Genet, D-91058 Erlangen, Germany

来源：

FUTURE ONCOLOGY | 2009年 / 5卷 / 08期

关键词：

leukemia; mixed-lineage leukemia; MLL; MLL fusions; transformation; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; HOX GENE-EXPRESSION; MLL FUSION PROTEINS; CHRONIC LYMPHOCYTIC-LEUKEMIA; PROTO-ONCOPROTEIN MLL; BONE-MARROW-CELLS; HISTONE H3; 11Q23; TRANSLOCATIONS; INFANT-LEUKEMIA;

D O I：

10.2217/FON.09.96

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Genomic rearrangements of the locus 11q23 are frequently observed in aggressive acute leukemias with poor prognosis. These chromosomal aberrations fuse the mixed-lineage leukemia (MLL) gene to one of more than 50 partners. The resulting mixed-lineage leukemia fusions often code for chimeric transcriptional activators, which are able to transform normal hematopoietic cells through the deregulation of leukemogenic target genes, This review provides a concise overview about the known functions encoded in MLL and the respective fusion partners. Additionally, the roles of some target genes, as well as co-factors of mixed-lineage leukemia fusion proteins, are described with an emphasis on recent advances potentially uncovering novel therapeutic targets.

引用

页码：1271 / 1281

页数：11

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