Central hyperventilation related to administration of topiramate

被引:13
作者
Laskey, AL
Korn, DE
Moorjani, BI
Patel, NC
Tobias, JD
机构
[1] Univ Missouri, Hlth Sci Ctr M658, Dept Child Hlth, Columbia, MO 65212 USA
[2] Univ Missouri, Dept Neurol, Columbia, MO 65212 USA
[3] Univ Missouri, Dept Anesthesiol, Columbia, MO 65212 USA
关键词
D O I
10.1016/S0887-8994(99)00143-5
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Topiramate is a recently released antiepileptic agent used in the treatment of patients with refractory seizure disorders. In addition to its antiepileptogenic activities, it results in inhibition of carbonic anhydrase isoenzymes II and TV, which are present in the central nervous system. A 15-year-old female who presented with hyperpnea and primary respiratory alkalosis is reported. Other possible etiologies of the central hyperventilation syndrome were excluded. The problem resolved within 24 hours after discontinuing topiramate. (C) 2000 by Elsevier Science Inc. All rights reserved.
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收藏
页码:305 / 308
页数:4
相关论文
共 10 条
[1]   CENTRAL NEUROGENIC HYPERVENTILATION IN A CONSCIOUS PATIENT WITH A PRIMARY CEREBRAL LYMPHOMA [J].
BATEMAN, DE ;
GIBSON, GJ ;
HUDGSON, P ;
TOMLINSON, BE .
ANNALS OF NEUROLOGY, 1985, 17 (04) :402-405
[2]   Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages [J].
Faught, E ;
Wilder, BJ ;
Ramsay, RE ;
Reife, RA ;
Kramer, LD ;
Pledger, GW ;
Karim, RM ;
Barr, A ;
Fischer, J ;
Bergen, D ;
Boor, D ;
Browne, T ;
Davenport, J ;
Dichter, M ;
Drake, M ;
Kuzniecky, R ;
Mamdani, M ;
McCutchen, C ;
Naritoku, D ;
Potolicchio, S ;
Ramani, V ;
Ramsay, R ;
Shinnar, S ;
So, E ;
Wilder, B .
NEUROLOGY, 1996, 46 (06) :1684-1690
[3]   CARBONIC ANHYDRASE-IV ON BRAIN CAPILLARY ENDOTHELIAL-CELLS - A MARKER ASSOCIATED WITH THE BLOOD-BRAIN-BARRIER [J].
GHANDOUR, MS ;
LANGLEY, OK ;
ZHU, XL ;
WAHEED, A ;
SLY, WS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :6823-6827
[4]   FUNCTIONAL SIGNIFICANCE OF CARBONIC ANHYDRASE IN CENTRAL NERVOUS SYSTEM [J].
NAIR, V ;
BAU, D .
BRAIN RESEARCH, 1971, 31 (01) :185-&
[5]   CENTRAL NEUROGENIC HYPERVENTILATION IN MAN [J].
PLUM, F ;
SWANSON, AG .
ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 1959, 81 (05) :535-549
[6]   CENTRAL NEUROGENIC HYPERVENTILATION IN AN AWAKE PATIENT WITH BRAIN-STEM ASTROCYTOMA [J].
RODRIGUEZ, M ;
BAELE, PL ;
MARSH, HM ;
OKAZAKI, H .
ANNALS OF NEUROLOGY, 1982, 11 (06) :625-628
[7]   TOPIRAMATE - PRECLINICAL EVALUATION OF A STRUCTURALLY NOVEL ANTICONVULSANT [J].
SHANK, RP ;
GARDOCKI, JF ;
VAUGHT, JL ;
DAVIS, CB ;
SCHUPSKY, JJ ;
RAFFA, RB ;
DODGSON, SJ ;
NORTEY, SO ;
MARYANOFF, BE .
EPILEPSIA, 1994, 35 (02) :450-460
[8]  
TOBIAS JD, 1991, PEDIATRICS, V88, P818
[9]   Noninvasive monitoring of carbon dioxide during respiratory failure in toddlers and infants: End-tidal versus transcutaneous carbon dioxide [J].
Tobias, JD ;
Meyer, DJ .
ANESTHESIA AND ANALGESIA, 1997, 85 (01) :55-58