Central hyperventilation related to administration of topiramate

被引：13

作者：

Laskey, AL

Korn, DE

Moorjani, BI

Patel, NC

Tobias, JD

机构：

[1] Univ Missouri, Hlth Sci Ctr M658, Dept Child Hlth, Columbia, MO 65212 USA

[2] Univ Missouri, Dept Neurol, Columbia, MO 65212 USA

[3] Univ Missouri, Dept Anesthesiol, Columbia, MO 65212 USA

来源：

PEDIATRIC NEUROLOGY | 2000年 / 22卷 / 04期

关键词：

D O I：

10.1016/S0887-8994(99)00143-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Topiramate is a recently released antiepileptic agent used in the treatment of patients with refractory seizure disorders. In addition to its antiepileptogenic activities, it results in inhibition of carbonic anhydrase isoenzymes II and TV, which are present in the central nervous system. A 15-year-old female who presented with hyperpnea and primary respiratory alkalosis is reported. Other possible etiologies of the central hyperventilation syndrome were excluded. The problem resolved within 24 hours after discontinuing topiramate. (C) 2000 by Elsevier Science Inc. All rights reserved.

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收藏

页码：305 / 308

页数：4

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