Health-related quality of life of patients with juvenile idiopathic arthritis coming from 3 different geographic areas.: The PRINTO multinational quality of life cohort study

被引:107
作者
Gutierrez-Suarez, R.
Pistorio, A.
Cruz, A. Cespedes
Norambuena, X.
Flato, B.
Rumba, I.
Harjacek, M.
Nielsen, S.
Susic, G.
Mihaylova, D.
Huemer, C.
Melo-Gomes, J.
Andersson-Gare, B.
Balogh, Z.
De Cunto, C.
Vesely, R.
Pagava, K.
Romicka, A. M.
Burgos-Vargas, R.
Martini, A.
Ruperto, N.
机构
[1] Univ Genoa, PRINTO, IRCCS, I-16147 Genoa, Italy
[2] IRCCS G Gaslini, Serv Epidemiol & Biostat, Genoa, Italy
[3] Univ Hosp, Rikshosp, Dept Rheumatol, Oslo, Norway
[4] Univ Latria, Riga, Latvia
[5] Univ Zagreb, Childrens Hosp, Dept Pediat Immunol Rheumatol, Zagreb, Croatia
[6] Rigshosp, Juliane Marie Ctr, Pediat Klin 2, Copenhagen, Denmark
[7] Inst Rheumatol, Dept Pediat Rheumatol, Belgrade, Serbia
[8] Univ Sofia, Childrens Hosp, Dept Paediat Rheumatol, BU-1126 Sofia, Bulgaria
[9] Landeskranken Haus Bregenz, Bregnez, Austria
[10] Inst Portugues Reumatol Pediat Reumatol, Lisbon, Portugal
[11] Ryhov Cty Hosp, Dept Child Publ hlth, Jonkoping, Sweden
[12] Natl Inst Rheumatism & Physiotherapy, Dept Gen & Pediat Rheumatol 3, Budapest, Hungary
[13] Hosp Italiano Buenos Aires, Pediat Rheumatol & Immunol Sect, Buenos Aires, DF, Argentina
[14] Detska Fak Nemocn, Dept Pediat 1, Kosice, Slovakia
[15] Tbilisi State Med Univ, Dept Pediat & Adolescent Med, Tbilisi Hosp 1, Tbilisi, Georgia
[16] Tbilisi State Med Univ, Dept Pediat & Adolescent Med, Georgian Sci Practical Rheumatol Ctr, Tbilisi, Georgia
[17] Inst Rheumatol, Paediat Clin, Warsaw, Poland
[18] Hosp Gen Mexico City, Dept Rheumatol, Mexico City, DF, Mexico
[19] Hosp Gen Mexico City, Fac Med, Mexico City, DF, Mexico
[20] Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico
[21] Univ Genoa, IRCCS G Gaslini, I-16126 Genoa, Italy
[22] Univ Genoa, Dipartimento Pediat, I-16126 Genoa, Italy
关键词
juvenile idiopathic arthritis; quality of life; disability; pain; CROSS-CULTURAL DIFFERENCES; CHILDREN; PAIN;
D O I
10.1093/rheumatology/kel218
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives. To compare health-related quality of life (HRQL) and to identify clinical determinants for poor HRQL of patients with juvenile idiopathic arthritis (JIA) coming from three geographic areas. Methods. The HRQL was assessed through the Child Health Questionnaire (CHQ). A total of 30 countries were included grouped in three geographic areas: 16 countries in Western Europe; 10 in Eastern Europe; and four in Latin America. Potential determinants of poor HRQL included demographic data, physician's and parent's global assessments, measures of joint inflammation, disability as measured by Childhood Health Assessment Questionnaire (CHAQ) and erythrocyte sedimentation rate. Poor HRQL was defined as a CHQ physical summary score (PhS) or psychosocial summary score (PsS) < 2 S. D. from that of healthy children. Results. A total of 3167 patients with JIA, younger than 18 yrs, were included in this study. The most affected health concepts (< 2 S. D. from healthy children) that differentiate the three geographic areas include physical functioning, bodily pain/discomfort, global health, general health perception, change in health with respect to the previous year, self-esteem and family cohesion. Determinants for poor HRQL were similar across geographic areas with physical well-being mostly affected by the level of disability while the psychosocial well-being by the intensity of pain. Conclusion. We found that patients with JIA have a significant impairment of their HRQL compared with healthy peers, particularly in the physical domain. Disability and pain are the most important determinants of physical and psychosocial well-being irrespective of the geographic area of origin.
引用
收藏
页码:314 / 320
页数:7
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