Mapping of the dilute-opisthotonus (dop) gene on chromosome 8 of the rat

被引：5

作者：

Ohno, K ^{[1
]}

Kanou, Y ^{[1
]}

Oda, S ^{[1
]}

Wakasugi, N ^{[1
]}

Inouye, M ^{[1
]}

Yamamura, H ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH AGR SCI,CHIKUSA KU,NAGOYA,AICHI 46401,JAPAN

来源：

EXPERIMENTAL ANIMALS | 1996年 / 45卷 / 01期

关键词：

ataxic mutant rat; dilute-opisthotonus (dop); gene mapping;

D O I：

10.1538/expanim.45.71

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The rat dilute-opisthotonus (dop) autosomal recessive gene, causing ataxia and coat color dilution, was mapped on chromosome 8 by PCR-amplified microsatellite markers. To facilitate the linkage analysis, an intersubspecific cross with a Japanese wild rat strain was used. The recombination frequencies were 12.8% between Apoc3 and dop, and 32.1% between dop and Mylc1v. The following order of three genes is proposed; Apoc3-dop-Mylc1v. This mutation appears to be homologous to dilute-lethal (d(l)) of the mouse in terms of clinical symptoms, coat color effect and chromosomal location of the gene loci.

引用

页码：71 / 75

页数：5

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