Tau gene polymorphisms and apolipoprotein E ε4 may interact to increase risk for Alzheimer's disease

被引:50
作者
Lilius, L
Fabre, SF
Basun, H
Forsell, C
Axelman, K
Mattila, K
Andreadis, A
Viitanen, M
Winblad, B
Fratiglioni, L
Lannfelt, L [1 ]
机构
[1] Novum, Karolinska Inst, Div Geriatr Med, KFC,NEUROTEC, S-14186 Huddinge, Sweden
[2] Eunice Kennedy Shriver Ctr Mental Retardat Inc, Dept Biomed Sci, Waltham, MA 02154 USA
[3] Stockholm Gerontol Res Ctr, S-11382 Stockholm, Sweden
关键词
Alzheimer's disease; tau; gene; polymorphism; apolipoprotein E;
D O I
10.1016/S0304-3940(99)00833-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In an effort to analyze the genetic role of tau in Alzheimer's disease (AD), 17 polymorphisms were identified. Eleven of these polymorphisms were in complete linkage disequilibrium and segregated as two haplotypes, A and B. The A and B haplotypes were investigated in 269 AD cases and 238 controls from two different sources, a clinic-based group (mean age of onset 65 +/- 9 years), and a population-based group (mean age of onset 80 +/- 5 years). A synergistic effect between the common tau genotype AA and apolipoprotein E (APOE epsilon 4) was found in the clinic-based AD group. Our study suggests that the common tau genotype AA may interact with APQE epsilon 4 in increasing the risk of AD in a subgroup of the AD population. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:29 / 32
页数:4
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