Potassium organotrifluoroborates: new partners in catalytic enantioselective conjugate additions to enones

被引：84

作者：

Pucheault, M ^{[1
]}

Darses, S ^{[1
]}

Genet, JP ^{[1
]}

机构：

[1] Ecole Natl Super Chim Paris, Lab Synth Select Organ & Prod Nat, CNRS, UMR 7573, F-75231 Paris 05, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 35期

关键词：

organotrifluoroborates; asymmetric catalysis; 1,4-addition; rhodium catalyst;

D O I：

10.1016/S0040-4039(02)01288-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Potassium organotrifluoroborates, highly stable organoboron derivatives and easily accessible from organolithiated reagents, can achieve rhodium(I)-catalyzed asymmetric 1,4-additions to enones using binap as chiral ligand. This reaction proceeds in nearly quantitative yields to afford beta-functionalized ketones with e.e. up to 98%. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6155 / 6157

页数：3

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