Measurement of enantiomeric excess using molecularly imprinted polymers

被引:21
作者
Chen, YZ [1 ]
Shimizu, KD [1 ]
机构
[1] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA
关键词
D O I
10.1021/ol026336q
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new method is presented for the measurement of enantiomeric excess (ee) utilizing molecularly imprinted polymers (MIPs). The method is demonstrated to be accurate and rapid, as the ee values can be calculated from straightforward concentration measurements. The MIP-based assay can also be adapted to measure the ee of samples of differing initial concentrations.
引用
收藏
页码:2937 / 2940
页数:4
相关论文
共 41 条
[1]  
Angelaud R, 2000, CHIRALITY, V12, P544, DOI 10.1002/(SICI)1520-636X(2000)12:5/6<544::AID-CHIR43>3.3.CO
[2]  
2-1
[3]  
[Anonymous], 2001, MOL IMPRINTED POLYM
[4]   Influence of thermal annealing on the thermodynamic and mass transfer kinetic properties of D- and L-phenylalanine anilide on imprinted polymeric stationary phases [J].
Chen, YB ;
Kele, M ;
Sajonz, P ;
Sellergren, B ;
Guiochon, G .
ANALYTICAL CHEMISTRY, 1999, 71 (05) :928-938
[5]   Discovery of chiral catalysts through ligand diversity: Ti-catalyzed enantioselective addition of TMSCN to meso epoxides [J].
Cole, BM ;
Shimizu, KD ;
Krueger, CA ;
Harrity, JPA ;
Snapper, ML ;
Hoveyda, AH .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (15) :1668-1671
[6]  
Dahmen S, 2001, SYNTHESIS-STUTTGART, P1431
[7]  
Francis MB, 1999, ANGEW CHEM INT EDIT, V38, P937, DOI 10.1002/(SICI)1521-3773(19990401)38:7<937::AID-ANIE937>3.0.CO
[8]  
2-O
[9]   Investigation of a new family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening [J].
Gennari, C ;
Ceccarelli, S ;
Piarulli, U ;
Montalbetti, CAGN ;
Jackson, RFW .
JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (16) :5312-5313
[10]  
Gilbertson SR, 2001, PROG INORG CHEM, V50, P433