Synthesis of chiral, non-racemic aldols from chiral β-hydroxy-Weinreb amides prepared by enantioselective Reformatsky-like reaction induced by chiral β-aminoalcohols

被引：35

作者：

Andrés, JM ^{[1
]}

Pedrosa, R ^{[1
]}

Pérez-Encabo, A ^{[1
]}

机构：

[1] Univ Valladolid, Fac Ciencias, Dept Quim Organ, E-47011 Valladolid, Spain

来源：

TETRAHEDRON | 2000年 / 56卷 / 09期

关键词：

chiral aminoalcohols; enantioselective synthesis; Reformatsky reaction; stereoselective aldol reaction;

D O I：

10.1016/S0040-4020(99)01070-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral 1,2-aminoalcohols catalyze enantioselective Reformatsky addition of zinc derivatives of alpha-bromo Weinreb amides. Reaction of Grignard reagents with the resulting beta-hydroxy N-methoxy-N-methyl amides allowed the preparation of beta-hydroxy ketones regio- and enantioselectively. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1217 / 1223

页数：7

共 28 条

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