Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes

被引：301

作者：

Cao, Zehui ^{[2
]}

Tong, Rong ^{[1
]}

Mishra, Abhijit ^{[1
]}

Xu, Weichen ^{[2
]}

Wong, Gerard C. L. ^{[1
]}

Cheng, Jianjun ^{[1
]}

Lu, Yi ^{[1
,2
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 35期

基金：

美国国家科学基金会;

关键词：

aptamers; cisplatin; drug delivery; liposomes; SYSTEMATIC EVOLUTION; CANCER-CELLS; MACROMOLECULAR THERAPEUTICS; ANTIPROLIFERATIVE ACTIVITY; ANTI-HER2; IMMUNOLIPOSOMES; MOLECULAR RECOGNITION; RNA APTAMERS; TUMOR-CELLS; CISPLATIN; GROWTH;

D O I：

10.1002/anie.200901452

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolinaptamer- conjugated, cisplatin-encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF-7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the aptamer as an antidote. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

收藏

页码：6494 / 6498

页数：5

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