CREB and the formation of long-term memory

被引：330

作者：

Yin, JCP

Tully, T

机构：

[1] Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1996年 / 6卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-4388(96)80082-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of the transcription factor accelerate the process. These results have led to the recent hypothesis that CREB is pivotal in the switch from short-term (protein synthesis independent) to long-term (protein synthesis dependent) memory.

引用

收藏

页码：264 / 268

页数：5

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