TGF-β, a 'double agent' in the immune pathology war

被引：67

作者：

Cua, DJ ^{[1
]}

Kastelein, RA ^{[1
]}

机构：

[1] Schering Plough Biopharma, Discovery Res, Palo Alto, CA 94304 USA

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 06期

关键词：

D O I：

10.1038/ni0606-557

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper cells that produce interleukin 17 can promote a range of immune-mediated inflammatory diseases. Papers in Nature and Immunity suggest transforming growth factor-beta promotes the differentiation of these pathogenic cells.

引用

页码：557 / 559

页数：4

共 12 条

[1] BETTELLI E, 2006, NATURE 0430
[2] Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
Cua, DJ
Sherlock, J
Chen, Y
Murphy, CA
Joyce, B
Seymour, B
Lucian, L
To, W
Kwan, S
Churakova, T
Zurawski, S
Wiekowski, M
Lira, SA
Gorman, D
Kastelein, RA
Sedgwick, JD
[J]. NATURE, 2003, 421 (6924) : 744 - 748
[3] The role of interleukin-12 in human infectious diseases: only a faint signature
Fieschi, C
Casanova, JL
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (06) : 1461 - 1464
[4] Cutting edge:: Roles of toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection
Happel, KI
Zheng, MQ
Young, E
Quinton, LJ
Lockhart, E
Ramsay, AJ
Shellito, JE
Schurr, JR
Bagby, GJ
Nelson, S
Kolls, JK
[J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (09) : 4432 - 4436
[5] Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Harrington, LE
Hatton, RD
Mangan, PR
Turner, H
Murphy, TL
Murphy, KM
Weaver, CT
[J]. NATURE IMMUNOLOGY, 2005, 6 (11) : 1123 - 1132
[6] IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, CL
Chen, Y
Blumenschein, WM
Mattson, J
Basham, B
Sedgwick, JD
McClanahan, T
Kastelein, RA
Cua, DJ
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) : 233 - 240
[7] MANGAN PR, 2006, NATURE 0430
[8] Divergent pro- and Antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
Murphy, CA
Langrish, CL
Chen, Y
Blumenschein, C
McClanahan, T
Kastelein, RA
Sedgwick, JD
Cua, DJ
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) : 1951 - 1957
[9] Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
Oppmann, B
Lesley, R
Blom, B
Timans, JC
Xu, YM
Hunte, B
Vega, F
Yu, N
Wang, J
Singh, K
Zonin, F
Vaisberg, E
Churakova, T
Liu, MR
Gorman, D
Wagner, J
Zurawski, S
Liu, YJ
Abrams, JS
Moore, KW
Rennick, D
de Waal-Malefyt, R
Hannum, C
Bazan, JF
Kastelein, RA
[J]. IMMUNITY, 2000, 13 (05) : 715 - 725
[10] A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H
Li, ZX
Yang, XO
Chang, SH
Nurieva, R
Wang, YH
Wang, Y
Hood, L
Zhu, Z
Tian, Q
Dong, C
[J]. NATURE IMMUNOLOGY, 2005, 6 (11) : 1133 - 1141

← 1 2 →