Inhibition of mitochondrial calcium uptake slows down relaxation in mitochondria-rich skeletal muscles

被引:40
作者
Gillis, JM
机构
[1] Department of Physiology, Catholic University of Louvain, Faculty of Medicine, 1200 Bruxelles
关键词
D O I
10.1023/A:1018603032590
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Isolated fibres from various muscles were skinned mechanically in oil. From a Ca2+-loaded micropipette, local applications of Ca2+ were made. These produced a limited contraction which relaxed spontaneously. The time-course of sarcomere shortening and re-lengthening was recorded by microcinephotography. Application of Ruthenium Red, a potent and specific inhibitor of Ca2+ uptake by mitochondria, did not affect the contraction-relaxation cycles of typical glycolytic white fibres (frog sartorius, pigeon breast). By contrast, Ruthenium Red greatly;slowed down the relaxation rate in mitochondria-rich fibres (rat soleus and rabbit masseter). In these fibres, Ca2+ uptake by mitochondria seems to play an active role in promoting relaxation.
引用
收藏
页码:473 / 483
页数:11
相关论文
共 28 条
  • [1] ASHLEY CC, 1974, CALCIUM BINDING PROT, P609
  • [2] ASHLEY CC, 1965, J PHYSL, V179, P32
  • [3] Time course of calcium transients derived from Fura-2 fluorescence measurements in single fast twitch fibres of adult mice and rat myotubes developing in primary culture
    Bakker, AJ
    Head, SI
    Stephenson, DG
    [J]. CELL CALCIUM, 1997, 21 (05) : 359 - 364
  • [4] SARCOPLASMIC-RETICULUM CALCIUM RELEASE IN FROG SKELETAL-MUSCLE FIBERS ESTIMATED FROM ARSENAZO-III CALCIUM TRANSIENTS
    BAYLOR, SM
    CHANDLER, WK
    MARSHALL, MW
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1983, 344 (NOV): : 625 - 666
  • [5] CALCIUM TRANSIENTS IN ISOLATED AMPHIBIAN SKELETAL-MUSCLE FIBERS - DETECTION WITH AEQUORIN
    BLINKS, JR
    RUDEL, R
    TAYLOR, SR
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1978, 277 (APR): : 291 - 323
  • [6] INTRACELLULAR CALCIUM HOMEOSTASIS
    CARAFOLI, E
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 : 395 - 433
  • [7] MODULATION BY FATTY-ACIDS OF CA2+ FLUXES IN SARCOPLASMIC-RETICULUM VESICLES
    CARDOSO, CM
    DEMEIS, L
    [J]. BIOCHEMICAL JOURNAL, 1993, 296 : 49 - 52
  • [8] CALCIUM TRANSIENTS IN INTACT RAT SKELETAL-MUSCLE FIBERS IN AGAROSE-GEL
    CARROLL, SL
    KLEIN, MG
    SCHNEIDER, MF
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1995, 269 (01): : C28 - C34
  • [9] Mitochondrial free calcium transients during excitation-contraction coupling in rabbit cardiac myocytes
    Chacon, E
    Ohata, H
    Harper, IS
    Trollinger, DR
    Herman, B
    Lemasters, JJ
    [J]. FEBS LETTERS, 1996, 382 (1-2): : 31 - 36
  • [10] DYNAMIC PROPERTIES OF MAMMALIAN SKELETAL-MUSCLES
    CLOSE, RI
    [J]. PHYSIOLOGICAL REVIEWS, 1972, 52 (01) : 129 - +