HLA class II genes associated with REM sleep behavior disorder

被引：55

作者：

Schenck, CH

GarciaRill, E

Segall, M

Noreen, H

Mahowald, MW

机构：

[1] HENNEPIN CTY MED CTR,DEPT PSYCHIAT,MINNEAPOLIS,MN 55415

[2] HENNEPIN CTY MED CTR,DEPT NEUROL,MINNEAPOLIS,MN 55415

[3] UNIV MINNESOTA,SCH MED,MINNEAPOLIS,MN 55455

[4] UNIV ARKANSAS MED SCI HOSP,DEPT ANAT,LITTLE ROCK,AR 72205

[5] UNIV MINNESOTA,DEPT LAB MED & PATHOL,MINNEAPOLIS,MN 55455

[6] UNIV MINNESOTA HOSP & CLIN,IMMUNOL HISTOCOMPATIBIL LAB,MINNEAPOLIS,MN

来源：

ANNALS OF NEUROLOGY | 1996年 / 39卷 / 02期

关键词：

D O I：

10.1002/ana.410390216

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Twenty-five white men with rapid eye movement (REM) sleep behavior disorder, but without narcolepsy, underwent HLA class II antigen typing; 84% (N = 21) were DQw1 (DQB1*05,06) positive (28% [N = 7] were DR2 positive); DQB1*0501 (N = 9) and DQB1*0602 (N = 7) were the most common phenotypes. The 84% DQw1 rate in men with REM sleep behavior disorder was significantly greater (p = 0.015) than the 56% DQw1 rate found in a local white comparison group (N = 66), and was greater than the 39 to 66% DQw1 rates published for 12 white groups (N = 40-418/group). Thus, another disorder of REM sleep dysregulation (besides narcolepsy) appears to be strongly associated with specific HLA class II genes.

引用

页码：261 / 263

页数：3

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