The neurotrophins act synergistically with LIF and members of the TGF-β superfamily to promote the survival of spiral ganglia neurons in vitro

被引：63

作者：

Marzella, PL

Gillespie, LN

Clark, GM

Bartlett, PF

Kilpatrick, TJ

机构：

[1] Univ Melbourne, Royal Victorian Eye & Ear Hosp, Dept Otolaryngol, E Melbourne, Vic 3002, Australia

[2] Walter & Eliza Hall Inst Med Res, Dev & Neuroimmunol Lab, Parkville, Vic 3052, Australia

来源：

HEARING RESEARCH | 1999年 / 138卷 / 1-2期

关键词：

auditory neuron; pharmacological therapy; cytokine; neurotrophin; neuronal degeneration; neurotrophic effect;

D O I：

10.1016/S0378-5955(99)00152-5

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

A number of growth factor families have been implicated in normal inner ear development, auditory neuron survival and protection. Several growth factors, including transforming growth factor-beta 5 (TGF-beta 5) and TGF-beta 3, neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF) and leukemia inhibitory factor (LIF) were tested for their ability, individually or in combination, to promote auditory neuron survival in dissociated cell cultures of early rat post-natal spiral ganglion cells (SGCs). The results indicate that at discrete concentrations all growth factors act in an additive fashion and some in synergy when promoting neuronal survival. These findings support the hypothesis that growth factors from different families may be interdependent when sustaining neuronal integrity. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：73 / 80

页数：8

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