Effect of cell culture conditions on the anticytomegalovirus activity of maribavir

被引：50

作者：

Chou, SW

Van Wechel, LC

Marousek, GI

机构：

[1] VA Med Ctr, P3ID, Med & Res Serv, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Portland, OR USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 07期

关键词：

D O I：

10.1128/AAC.00207-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.

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收藏

页码：2557 / 2559

页数：3

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