Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions

被引：235

作者：

Kienesberger, Petra C. ^{[1
]}

Oberer, Monika ^{[1
]}

Lass, Achim ^{[1
]}

Zechner, Rudolf ^{[1
]}

机构：

[1] Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria

来源：

JOURNAL OF LIPID RESEARCH | 2009年 / 50卷

关键词：

PNPLA; ATGL; adiponutrin; GS2; GS2-like; NTE; NRE; iPLA(2)gamma; PLA2G6; ADIPOSE TRIGLYCERIDE LIPASE; NEUROPATHY TARGET ESTERASE; LIPID STORAGE DISEASE; CALCIUM-INDEPENDENT PHOSPHOLIPASE-A(2)GAMMA; CHANARIN-DORFMAN-SYNDROME; HYDROLASE ACTIVITY; INSULIN-SECRETION; 3T3-L1; ADIPOCYTES; ACYL HYDROLASE; FATTY LIVER;

D O I：

10.1194/jlr.R800082-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human genome expresses nine patatin-like phospholipase domain containing proteins (PNPLA1-9). Members of this family share a protein domain discovered initially in patatin, the most abundant protein of the potato tuber. Patatin is a lipid hydrolase with an unusual folding topology that differs from classical lipases. Mammalian PNPLAs include lipid hydrolases with specificities for diverse substrates such as triacylglycerols, phospholipids, and retinol esters. Analysis of induced mutant mouse models and the clinical phenotype of patients with mutations revealed important insights into the physiological role of several members of the PNPLA family.jlr This review aims to summarize current knowledge of PNPLA proteins and to document their emerging importance in lipid and energy homeostasis.-Kienesberger, P. C., M. Oberer, A. Lass, and R. Zechner. Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. J. Lipid Res. 2009. S63-S68.

引用

页码：S63 / S68

页数：6

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