Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma

被引：43

作者：

Hashimoto, T

Uchida, K

Okayama, N

Imate, Y

Suehiro, Y

Hamanaka, Y

Ueyama, Y

Shinozaki, F

Yamashita, H

Hinoda, Y

机构：

[1] Yamaguchi Univ, Sch Med, Dept Clin Lab Sci, Ube, Yamaguchi 7558505, Japan

[2] Yamaguchi Univ, Sch Med, Dept Otolaryngol, Ube, Yamaguchi 7558505, Japan

[3] Yamaguchi Univ, Sch Med, Dept Oral & Maxillofacial Surg, Ube, Yamaguchi 7558505, Japan

来源：

CANCER LETTERS | 2004年 / 211卷 / 01期

关键词：

matrix metalloproteinase-1; matrix metalloproteinase-3; head and neck squamous cell carcinoma; polymorphism;

D O I：

10.1016/j.canlet.2004.01.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To explore the relation of the MMP-1 1G/2G and MMP-3 5A/6A promoter polymorphisms with head and neck squamous cell carcinoma (HNSCC), DNA specimens extracted from peripheral blood cells of HNSCC patients and healthy controls were genotyped. The frequency of the MMP-1 2G/2G genotype was significantly higher in HNSCC patients (n = 140) than in age- and sex-matched controls (n = 223) (P = 0.042; OR, 1.56). In the MMP-3 polymorphism, there was no significant difference in the genotype distribution between patients and controls. These data suggest that the MMP-1 promoter polymorphism may be associated with HNSCC. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：19 / 24

页数：6

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