Numb: "Adapting" Notch for endocytosis

被引：27

作者：

Jafar-Nejad, H

Norga, KK

Bellen, HJ

机构：

[1] Baylor Coll Med, Howard Hughes Med Inst, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Baylor Coll Med, Texas Childrens Canc Ctr, Houston, TX 77030 USA

[3] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

来源：

DEVELOPMENTAL CELL | 2002年 / 3卷 / 02期

关键词：

D O I：

10.1016/S1534-5807(02)00228-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During sensory organ precursor divisions in Drosophila, the numb gene product segregates asymmetrically into one of the two daughter cells, to which it confers a specific fate by inhibiting Notch signaling. In this issue of Developmental Cell, Berdnik et al. show that Numb recruits α-Adaptin and that this physical interaction plays a role in downregulating Notch, presumably by stimulating endocytosis of Notch.

引用

页码：155 / 156

页数：2

共 9 条

[1] The endocytic protein α-adaptin is required for numb-mediated asymmetric cell division in Drosophila [J].