Structure, function and regulation of carboxylesterases

被引：417

作者：

Satoh, Tetsuo ^{[1
]}

Hosokawa, Masakiyo

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chiba, Japan

[2] Ichikawa Gen Hosp, HAB Res Labs, Chiba 2728513, Japan

[3] Chiba Inst Sci, Fac Pharmaceut Sci, Chiba, Japan

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2006年 / 162卷 / 03期

关键词：

carboxylesterases; function; drug metabolism; gene expression; molecular structure; regulation; enzyme induction; novel nomenclature and classification;

D O I：

10.1016/j.cbi.2006.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review covers current developments in molecular-based studies of the structure and function of carboxylesterases. To allay the confusion of the classic classification of carboxylesterase isozymes, we have proposed a novel nomenclature and classification of mammalian carboxylesterases on the basis of molecular properties. In addition, mechanisms of regulation of gene expression of carboxylesterases by xenobiotics and involvement of carboxylesterase in drug metabolism and enzyme induction are also described. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

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收藏

页码：195 / 211

页数：17

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