Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold

被引：214

作者：

Boss, O ^{[1
]}

Samec, S ^{[1
]}

Dulloo, A ^{[1
]}

Seydoux, J ^{[1
]}

Muzzin, P ^{[1
]}

Giacobino, JP ^{[1
]}

机构：

[1] UNIV GENEVA,FAC MED,DEPT PHYSIOL,CH-1211 GENEVA 4,SWITZERLAND

来源：

FEBS LETTERS | 1997年 / 412卷 / 01期

关键词：

uncoupling protein; skeletal muscle; heart; brown adipose tissue; fasting; cold;

D O I：

10.1016/S0014-5793(97)00755-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The control of uncoupling protein-2 (UCP2) mRNA expression in rat brown adipose tissue (BAT), heart and skeletal muscles was examined, Cold exposure (48 h) increased UCP2 mRNA in BAT, heart and soleus muscle by 2.4-, 4.3- and 2.6-fold, respectively, Fasting (48 h) had no effect on UCP2 mRNA expression neither in BAT nor in heart, but markedly increased it in skeletal muscles, While the upregulation of UCP2 mRNA in response to cold exposure is in line with a putative uncoupling role for this protein in thermoregulatory thermogenesis, the unexpected upregulation of UCP2 in skeletal muscles in response to fasting seems inconsistent with its role as an uncoupling protein involved in dietary regulation of thermogenesis. (C) 1997 Federation of European Biochemical Societies.

引用

页码：111 / 114

页数：4

共 11 条

[1] Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
Boss, O
Samec, S
PaoloniGiacobino, A
Rossier, C
Dulloo, A
Seydoux, J
Muzzin, P
Giacobino, JP
[J]. FEBS LETTERS, 1997, 408 (01) : 39 - 42
[2] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION
CHOMCZYNSKI, P
SACCHI, N
[J]. ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) : 156 - 159
[3] SYMPATHETIC NERVOUS-SYSTEM RESPONSES TO COLD-EXPOSURE AND DIET IN RAT SKELETAL-MUSCLE
DULLOO, AG
YOUNG, JB
LANDSBERG, L
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (02): : E180 - E188
[4] Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
Fleury, C
Neverova, M
Collins, S
Raimbault, S
Champigny, O
LeviMeyrueis, C
Bouillaud, F
Seldin, MF
Surwit, RS
Ricquier, D
Warden, CH
[J]. NATURE GENETICS, 1997, 15 (03) : 269 - 272
[5] BROWN ADIPOSE-TISSUE THERMOGENESIS - INTERDISCIPLINARY STUDIES
HIMMSHAGEN, J
[J]. FASEB JOURNAL, 1990, 4 (11) : 2890 - 2898
[6] LANDSBERG L, 1978, NEW ENGL J MED, V298, P1295, DOI 10.1056/NEJM197806082982306
[7] RNA MOLECULAR-WEIGHT DETERMINATIONS BY GEL-ELECTROPHORESIS UNDER DENATURING CONDITIONS, A CRITICAL RE-EXAMINATION
LEHRACH, H
DIAMOND, D
WOZNEY, JM
BOEDTKER, H
[J]. BIOCHEMISTRY, 1977, 16 (21) : 4743 - 4751
[8] STARVATION-INDUCED CHANGES IN METABOLIC-RATE, BLOOD-FLOW, AND REGIONAL ENERGY-EXPENDITURE IN RATS
MA, SWY
FOSTER, DO
[J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1986, 64 (09) : 1252 - 1258
[9] THE NOVEL THERMOGENIC BETA-ADRENERGIC AGONIST RO-16-8714 INCREASES THE INTERSCAPULAR BROWN-FAT BETA-RECEPTOR ADENYLATE-CYCLASE AND THE UNCOUPLING-PROTEIN MESSENGER-RNA LEVEL IN OBESE (FA/FA) ZUCKER RATS
MUZZIN, P
REVELLI, JP
RICQUIER, D
MEIER, MK
ASSIMACOPOULOSJEANNET, F
GIACOBINO, JP
[J]. BIOCHEMICAL JOURNAL, 1989, 261 (03) : 721 - 724
[10] NONSHIVERING THERMOGENESIS AND THE THERMOGENIC CAPACITY OF BROWN FAT IN FASTED AND OR REFED MICE
TRAYHURN, P
JENNINGS, G
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (01): : R11 - R16

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