Nuclear Trafficking and Functions of Endocytic Proteins Implicated in Oncogenesis

被引：22

作者：

Borlido, Joana ^{[1
]}

Zecchini, Vincent ^{[1
]}

Mills, Ian G. ^{[1
]}

机构：

[1] CRUK Cambridge Res Inst, Urooncol Res Grp, Cambridge CB2 0RE, England

来源：

TRAFFIC | 2009年 / 10卷 / 09期

关键词：

adaptor; clathrin; endocytosis; network; signalling; transcription; HUNTINGTIN-INTERACTING PROTEIN-1; EPIDERMAL-GROWTH-FACTOR; BETA-ARRESTIN; SUBCELLULAR-LOCALIZATION; GLUCOCORTICOID-RECEPTOR; TRANSCRIPTION FACTOR; TSG101; PROTEIN; EXPORT SIGNAL; CLATHRIN; GENE;

D O I：

10.1111/j.1600-0854.2009.00922.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A subset of proteins predominantly associated with early endosomes or implicated in clathrin-mediated endocytosis can shuttle between the cytoplasm and the nucleus. Although the endocytic functions of these proteins have been extensively studied, much less effort has been expended in exploring their nuclear roles. Membrane trafficking proteins can affect signalling and proliferation and this can be achieved either at a nuclear or endocytic level. Furthermore, some proteins, such as Huntingtin interacting protein 1, are known as cancer biomarkers. This review will highlight the limits of our understanding of their nuclear functions and the relevance of this to signalling and oncogenesis.

引用

页码：1209 / 1220

页数：12

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