Synthesis of gold nanorod-embedded polymeric nanoparticles by a nanoprecipitation method for use as photothermal agents

被引：54

作者：

Kim, Eunjung ^{[2
]}

Yang, Jaemoon ^{[1
]}

Choi, Jihye ^{[2
]}

Suh, Jin-Suck ^{[1
]}

Huh, Yong-Min ^{[1
]}

Haam, Seungjoo ^{[2
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Radiol, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Engn, Dept Chem & Biomol Engn, Seoul 120749, South Korea

来源：

NANOTECHNOLOGY | 2009年 / 20卷 / 36期

关键词：

THERAPY; CELL; NANOHYBRIDS; SINGLE; GROWTH;

D O I：

10.1088/0957-4484/20/36/365602

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

For the synthesis of biocompatible photothermal agents, gold nanorod-embedded polymeric nanoparticles (GPNs) were synthesized using a nanoprecipitation method. Uniform gold nanorods (GNRs), which are sensitive to a photothermal effect by near-infrared (NIR) light, with an aspect ratio of 4.0 were synthesized by a seed-mediated growth method. The hydroxyl groups of polycaprolactone diol (PCL diOH) were modified by esterification with mercaptopropionic acid to give a dithiol (polycaprolactone dithiol, PCL diSH) as a phase transfer and capping agent. Subsequently, hexadecyltrimethylammonium bromide (CTAB), a stabilizer of GNRs, was exchanged and/or removed by PCL diSH. PCL diSH-coated GNRs were further wrapped in a hydrophilic polymer, Pluronic F127, as a stabilizer. These newly formulated GPNs exhibit excellent stability in water and a maximum absorbance in the NIR region indicating a highly efficient surface plasmon resonance effect, phenomena useful for photothermal agents.

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页数：7

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