At the crossroads of inflammation and cancer

被引：451

作者：

Clevers, H ^{[1
]}

机构：

[1] Ctr Biomed Genet, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

来源：

CELL | 2004年 / 118卷 / 06期

关键词：

D O I：

10.1016/j.cell.2004.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic inflammation and cancer are closely associated in the intestine. Anti-inflammatory medication reduces intestinal neoplasia, while colorectal cancer incidence is increased in ulcerative colitis. Cyclooxy-genases are key to both diseases, yet the molecular basis of the association remains incompletely understood. Two recent Cell (Greten et al., 2004; Rakoff-Nahoum et al., 2004) papers illuminate roles of Toll-like receptors and the NF-kappaB pathway in the control of epithelial homeostasis in health and disease.

引用

页码：671 / 674

页数：4

共 19 条

[1] NF-κB activation in cancer:: a challenge for ubiquitination- and proteasome-based therapeutic approach [J].

Amit, S ;

Ben-Neriah, Y .

SEMINARS IN CANCER BIOLOGY, 2003, 13 (01) :15-28

[2] Inferences, questions and possibilities in toll-like receptor signalling [J].

Beutler, B .

NATURE, 2004, 430 (6996) :257-263

[3] The two faces of IKK and NF-κB inhibition:: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion [J].

Chen, LW ;

Egan, L ;

Li, ZW ;

Greten, FR ;

Kagnoff, MF ;

Karin, M .

NATURE MEDICINE, 2003, 9 (05) :575-581

[4] A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS [J].

FEARON, ER ;

VOGELSTEIN, B .

CELL, 1990, 61 (05) :759-767

[5] IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer [J].

Greten, FR ;

Eckmann, L ;

Greten, TF ;

Park, JM ;

Li, ZW ;

Egan, LJ ;

Kagnoff, MF ;

Karin, M .

CELL, 2004, 118 (03) :285-296

[6] Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 [J].

Gupta, RA ;

DuBois, RN .

NATURE REVIEWS CANCER, 2001, 1 (01) :11-21

[7] Commensal host-bacterial relationships in the gut [J].

Hooper, LV ;

Gordon, JI .

SCIENCE, 2001, 292 (5519) :1115-1118

[8] Inflammation and cancer - IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation [J].

Itzkowitz, SH ;

Yio, XY .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2004, 287 (01) :G7-G17

[9] COX-2 inhibition and colorectal cancer [J].

Koehne, CH ;

DuBois, RN .

SEMINARS IN ONCOLOGY, 2004, 31 (02) :12-21

[10]

KRAOFFNAHOUM S, 2004, CELL, V118, P229

← 1 2 →