Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women A Randomized, Controlled Trial

被引:57
作者
Song, Yiqing [1 ]
Cook, Nancy R. [1 ,2 ]
Albert, Christine M. [1 ,3 ]
Van Denburgh, Martin [1 ]
Manson, JoAnn E. [1 ,2 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiol, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; SUPPLEMENTATION; SENSITIVITY; OBESITY; HYPERHOMOCYSTEINEMIA; METAANALYSIS;
D O I
10.2337/db09-0087
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE-Homocysteinemia may play an etiologic role in the pathogenesis of type 2 diabetes by promoting oxidative stress, systemic inflammation, and endothelial dysfunction. We investigated whether homocysteine-lowering treatment by B vitamin supplementation prevents the risk of type 2 diabetes. RESEARCH DESIGN AND METHODS-The Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS), a randomized, double-blind, placebo-controlled trial of 5,442 female health professionals aged >= 40 years with a history of cardiovascular disease (CVD) or three or more CVD risk factors, included 4,252 women free of diabetes at baseline. Participants were randomly assigned to either an active treatment group (daily intake of a combination pill of 2.5 mg folic acid, 50 mg vitamin 136, and 1 mg vitamin 1312) or to the placebo group. RESULTS-During a median follow-up of 7.3 years, 504 women had an incident diagnosis of type 2 diabetes. Overall, there was no significant difference between the active treatment group and the placebo group in diabetes risk (relative risk 0.94 [95% CI 0.79-1.11]; P = 0.46), despite significant lowering of homocysteine levels. Also, there was no evidence for effect modifications by baseline intakes of dietary folate, vitamin 136, and vitamin B12. In a sensitivity analysis, the null result remained for women compliant with their study pills (0.92 [0.76-1.10]; P = 0.36). CONCLUSIONS-Lowering homocysteine levels by daily supplementation with folic acid and vitamins 136 and B12 did not reduce the risk of developing type 2 diabetes among women at high risk for CVD. Diabetes 58:1921-1928, 2009
引用
收藏
页码:1921 / 1928
页数:8
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